Health informatics sits at the vibrant intersection of medicine, data science, and technology, transforming how we store, analyze, and utilize health information. This rapidly evolving field empowers clinicians and researchers to uncover patterns in patient data, improve diagnostic accuracy, and personalize treatment plans without getting lost in complex databases. By turning raw medical records into actionable insights, these innovations are reshaping the future of healthcare delivery and population health management.

At Gist.Science, we bridge the gap between cutting-edge research and public understanding by curating the latest preprints from medRxiv specifically within this domain. Our team processes every new submission in this category, providing both accessible plain-language explanations and detailed technical summaries to ensure the science is clear for everyone, from policymakers to curious readers. Below are the latest papers in health informatics, freshly distilled and ready for you to explore.

📄 health informatics

Joint Longitudinal-Survival Modelling of Patient-Reported Gastrointestinal Symptom Trajectories and Treatment Discontinuation in Irritable Bowel Syndrome: A Prospective Cohort Study from the Canadian Gut Project

This prospective cohort study of 2,847 Canadian IBS patients utilizes joint longitudinal-survival modeling to demonstrate that individual symptom trajectories are dynamically linked to treatment discontinuation, revealing that higher baseline severity and slower rates of symptom improvement significantly increase the risk of stopping therapy.

Thornton, E., Kellerman, J.2026-03-19
📄 health informatics

Clinician Experiences with Ambient AI Scribe Technology in Singapore: A Qualitative Study

This qualitative study of 28 clinicians at Singapore's Alexandra Hospital reveals that while ambient AI scribe technology offers significant potential to reduce administrative burden and enhance patient engagement, its successful implementation in Singapore's multilingual healthcare system requires addressing critical challenges related to documentation accuracy, workflow adaptation, and compliance with local privacy regulations.

Shankar, R., Goh, A., Xu, Q.2026-03-19
📄 health informatics

OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery

The paper introduces OpenScientist, an open-source agentic AI co-scientist that significantly accelerates biomedical discovery by autonomously executing complex data analyses and generating verifiable clinical insights across diverse case studies, reducing tasks that typically take weeks to mere minutes.

Roberts, K. F., Abrams, Z. B., Cappelletti, L., Moqri, M., Heugel, N., Caufield, J. H., Bourdenx, M., Li, Y., Banerjee (…)2026-03-18
📄 health informatics

Falsification Testing of Sepsis Prediction Models: Evaluating Independent Biological Signal After Controlling for Care-Process Intensity

This pre-registered falsification study across four clinical datasets demonstrates that while sepsis prediction models at elite academic centers primarily detect genuine biological signals rather than care-process intensity, they reveal a systematic and consequential divergence between clinical sepsis definitions and administrative coding that undermines the validity of regulatory metrics and AI benchmarks relying on the latter.

Dickens, A. R.2026-03-18
📄 health informatics

Persistent Proxy Discrimination in HIV Testing Prediction Models: A National Fairness Audit of 386,775 US Adults

This national fairness audit of 386,775 US adults demonstrates that enforcing demographic parity in HIV testing prediction models is inappropriate for differential-burden clinical contexts, as it significantly reduces screening access for high-risk populations and underscores the need for fairness metrics like equalized odds and calibration that align with clinical needs.

Farquhar, H.2026-03-16
📄 health informatics

WITHDRAWN: Causal Effects of Natural Language Processing-Enhanced Clinical Decision Support on Early Cognitive Impairment Detection: A Propensity Score Analysis Using Inverse Probability of Treatment Weighting

This paper is a withdrawn study from medRxiv that claimed to analyze the causal effects of natural language processing-enhanced clinical decision support on early cognitive impairment detection, but was retracted because it was submitted with false information.

Dimitriou, A., Foster, M.2026-03-16
📄 health informatics

WITHDRAWN: Blockchain-Enabled Health Information Exchange Efficiency Across South Korean Hospital Networks: A Stochastic Frontier Analysis with Bayesian Model Averaging

This withdrawn study utilized Stochastic Frontier Analysis with Bayesian Model Averaging on a panel of 247 South Korean hospital networks to demonstrate that blockchain-enabled health information exchange systems significantly improve technical efficiency compared to conventional platforms, even after controlling for endogeneity and model uncertainty.

Park, J.-H., Kim, S.-Y.2026-03-16